SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'af5ac4c209a29df7b481f992eb8f30d1851c335fd33c529b968b4567d0468549' 
  AND token = 'pjXVn6XFE8nfM1WL01WG3joQ2ZrwyvsukHMMpsxLRKQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}