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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '018401b9387bc3e381b21f56b9851e125446fbf1dc7a401d9fd67bb1b50e9a67' 
  AND token = 'fXFpVOZ0k+yiNFiC04EWvjKOnjCm2SqBN07RVbh9D40=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00045

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}