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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '259375e91dc0d4c179c63de5602ea2ccab4b8eb418a7bd76451d468b6faddc81' 
  AND token = 'wntuMpbDtq6wlb6t/Qi3XnZHsDcJx6i5RPusGi+kKgk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}