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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8abc756fd43e71aa97af798efec8fb2a2b09f5fc7dc53a153b98d4dbd6e07361' 
  AND token = '+fXKi/6Fs26JUz/PKaS3prdSmCzVdhTGIoUr0Kl8aWk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}