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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4e6ed12c16b041d518b100cf0132da73769aa411439c534780be18aa065670ed' 
  AND token = 'Di0dJLnSRXcbPeuh8+5NwAtrm1TvA+Ao/3NTfwHS45k=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}