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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '25d33c4f537756e67a01fd21cf5fa87a6086a998b0f92fdabc12cb4c99db81b9' 
  AND token = 'sm6nUxjlXMlnQPG99RDfSkqk1c44hCVfegV52bMoLcQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00023

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}