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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '465bed69b15772c2d736d1711c26d8c206b6443b5c8021ab95a4b497042fda34' 
  AND token = 'EDq6nd/5wcLWW0rgvZT8NFgdCyPW4qwvQ+CNVOwtpRY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}