SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6501c3241e9df37af472ecd2f93f6e6abee0cbe9eb89a8728b8fee7dc52979f8' 
  AND token = 'XnwxFDeMSuwzhSf8mWIwYk3vW8r8Z+RT6UH/FpENDm4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00016

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}