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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'ac8250c07bce8a9f23c91a3c681b969c4997f60733da3653acd9a30ae6b9404d' 
  AND token = 'EquY4SMUGT6faIqpaxy1qrQvP0mG11I5eYSx9Am+KF4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}