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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '35d0bfefabf38fe45799b371ff794d8f86bff73afd81bfb66a3da5fed86bcf49' 
  AND token = 'hIEZOB8hCXccKHe2or1BOgSD+5dQeWqoWjUtqkFC4P8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}