SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '154cf9d58fbe5c46e721f5c6f8aefb86fa41a560afae07f321d9f9a432d2f7fa' 
  AND token = 'DQzZ9f6eWv9wBeP8X4xiDGJS9C+xeDdLrWll11oDRP4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}