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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '399da8ae3a38bdec6151c4aa5da9c06777cfd8c21eab707fa483688744610fa8' 
  AND token = 'BL+/wVTKpdcbrVFW9n5tweFskOn8Ue/lcwCrkGUzZxQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}