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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'a42e27723731a7a69190ad6270678b5da8c7d8b208363b2ed522fa8aa9939b26' 
  AND token = 'Fxr63OQZhzQcctj+2Wa588wD8zsFiXASfqxKF3sveQU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}