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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'a37e63ad70f5ecfe36afc59b0a794e175bd98abc342a0163175ffafc490f2971' 
  AND token = 'FM2l6r2/VZK3PTkdCi4WYe+UjOCE8jiWxLkqlFa9zCc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}