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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '5051cda5b3ea8fc6a89011b9a4d196a38396a697aea6d2e640dc6e0d83847192' 
  AND token = 'ljzy7u2HU6VzWCwGSoOFi8WMG3xumx5ZBRF4QXB3ol8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}