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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8d9670a7ca4e232964576c05f4dd43bed9aeb553b5a9d09cd2964da2a7d44776' 
  AND token = 'FbOUM2w+yJpOLSyV0nI5WSE8YdnkKlO1GXcshCuH3Ac=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}