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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'a67e87423031bee3f72e99a08d4e08d964b9c11197ef62d871b843721c463144' 
  AND token = 'cU3SHjpUGlkDUu1UueS4kYXiCR6BSJZFv6PxiK54j0E=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}