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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6e52e6b47d5a4c537e9682d0b718b4af1be079d010990a1ee7a5f0ed70317dce' 
  AND token = 'aYisrn37SzuGazcqSRDtcHz0bYiNdsaTsBA6dQ6hKrk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}