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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'a174defd0280ee1eb8afa2a45cf36c78a22c75938f264f9d78b03bb3bc7841f1' 
  AND token = 'ADV1mF72F2ASP/2Lu4ViTZDuohlN1RSkYF4Qosxw+x4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}