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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e53e106f097b18abcf788867d482fc5d6109ecc854bcb5da6b4a3b4c2fe8422a' 
  AND token = 'rOaX+23TYRdTPRb7/ZnlzIWt3qkD90VA33Ev+5hb2k8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00014

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}