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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '9a1c968d0a90eade5000a04687538be1053ee17fbe406736b0e5aad4c632927c' 
  AND token = 'JelvW9h/gR8V+ohTSOHP4MCikV5/VzKlPDaKzwEb2IQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}