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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '72d2a43112e58e31e9705ab2402aaac18ac105e58caaa33de1b86ab32b3d3f44' 
  AND token = 'vbTpwd+v4NYGsNXtWlIjjN8x/drS9Qaj4OxTbHUjIjk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00041

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}