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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '45c6060b7f54ae9702e892ccbc47c2daa4b726f885c2c89a9d0a511e4a5ae3ba' 
  AND token = 'PfRRROZVMYMXOa+CizhO9GWwMdr6JL1cg2FjoM7Z/oo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}