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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6d45b87eccaf01654b451426ea3f77ab6aaa2c20aac621aeb9804acb44ce126c' 
  AND token = 'OPTA2r3JuDxhe1KF0INCIhB5msaiRxJ6QWBSCvRWYZ0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00036

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}