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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '221fcaa7f68f3006b227cb475de99f12557d0fb6cda35b58823477b12a75f34b' 
  AND token = '2Pd+AioYWzecQPcwtli8V1K72SscsR+udMqLl+B+abg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00039

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}