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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '21caa9f04ab004df2f287e0927323b13b20b1be879aa84becef217465b306fa2' 
  AND token = 'T0ufkdW72MUCTLs/buyOYgGfE1V9SfgVxK7Ai+fVo1U=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00056

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}