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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '7748149f010e7990e5fe257dbd1d3bc7ec45534ce5084009a4d5aaa5078e71b8' 
  AND token = 'r80y8sHnhTfBL1JCccEMViccvMSIbuB8hphgpp/iLFA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}