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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4e057aa83635cc1ba8f9273d45aca6d018a7789d8df06e0c8d475e137fa45448' 
  AND token = 'fmcXpMob3JDFEXB1vbFwIVkxml8F+Lq2Xf+OT5lMd7s=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}