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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '86e82e950830653b26e2c07127423f49c9ee23931f0e061cc7071c018286e03b' 
  AND token = 's3mXIIf1XDWQbcy+dKyrtwoPHMCn9cYEWDQh4w9nKsA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}