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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'a849410839a26ab31c6597d70bf6720da7cd4dc0ce250abaa5572b7fd103b85d' 
  AND token = 'PQwGDxbMboEvUyvWy1wGY8NGXJyeFFWhFrt4+ZSwhuE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}