SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'bfbf8025e41ede7b3a395096094e75e15dd95020afa67fad6d4a085bd9c20779' 
  AND token = 'w2xTdUlWMorwe+9D0YM8U6hjWhs7BDHFE72Ag4M9Drg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}