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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '16a6aacc39d3621b4f225937a84e90e59e0fa3abdaf15d2d8e1242f38a0e4859' 
  AND token = 'p1DCzzRdbPYDqXbpy7wYmX2oJGQvLCWx8CrHR4opDuE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}