SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'f8a3cce47db7bf454e32b2566141b5dbb340a9ec50b401434d690b4e3a090a28' 
  AND token = 'tniunqkxCaTnSNET9jDcU0JXkTmno+LbLcc3Fgjk308=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00036

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}