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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '80d7bff1f869be2c1eb324ab91fd09554e2f2c776b4edd45f58fa56c2f242641' 
  AND token = 'a97VMixk1AJXPaaLkTRfBse3XswFgAj4V6K9J0LbcBE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}