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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'da72385257d32b7f476d02d5e1dbe965213c24d652009cb5866c1517b8721c03' 
  AND token = 'pyZuXy+39snVIUDIlGTBvNzPGQ+6IZuDBdcTo2H+0Q8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}