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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '7e21b17fabdd7084546a57b1931f0056e927901c0ac7a0884e04ceaa6c8fade2' 
  AND token = 'ic7wnBlhCf5UMpW8GnXNwNhG+xAcYCG9e7EPPuUyqqI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}