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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'a0453c4e00ad55bf15319f30a5a0701c06bc60c10c12bcbafd4fa82a552ea0db' 
  AND token = 'RU3V4WHedDYbI5x1ZASC0kgV6l4xQo7EnPXeO/l3diw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}