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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '5127387f780b111eb5ea0412ddbf0a7e89b0cd3b4c47e8fcaf21c0b3585f7315' 
  AND token = 'hUMw4NjSp61w1flA209u39dxMMIA+ughK/g8NH3ms8s=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00042

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}