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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e4c808d92314d1c6f1c9596425d4dab4f32894720e65b49c3c35f2101b914694' 
  AND token = 'F3SeR/OgiyDEVeHDqs5OOqxgFvEbAOHT/oWsS3kD9Bg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}