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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '22645a5a74b5f2e329b541026f30329eb79f5a6c282c4be513a7b4262fdb5f18' 
  AND token = 'y2KY5rorS0trqqUUVCJCQgDSdjbzXxxaG3afDQc/m5I=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00039

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}