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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '461931f488d864c9181dea75f42880169a26596e6b1e3d90affbbadfd404c04e' 
  AND token = 'tsgyzbLVdg/wOUb8h0+egc2jt4p+MJKN9lcffNUha9A=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}