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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'f4452f378b9068a9005b024eb32b1ab5b5d7d5cc40522a8fd50c400fb5fa976b' 
  AND token = 'CEHD2KKbs83BywJK0lkHQcq1xlQ4zSiGLd1MN5oP6c0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}