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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e545a5f24506eb53cb44249e2666ef995735341407fea1c4e5dcee358d0a702b' 
  AND token = '7kdh2G1HvswrspRD+zyviw++He+OD0BxN0yCRCdQ4j4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}