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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '66d67d73c438e196480f710963a7e68bcc08626889c66b0c2d8891e283b9c863' 
  AND token = 'vXSGUt0oCLSijVLdeBYd+Kuq1LtYN9vBTeJ8WquZ8Sw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}