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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8c57bad3dc3690565a5c723a06d1171a0eeb07de3007cfc008f4f1bea8034b51' 
  AND token = '8oT1W9yDaEWab0UL6MuiIpa6BHxKO2fmDDQkGHfvzNY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}