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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6af12105a6e62246cb2e26095bc109576a0d57287eeefed6f021c49034c30f74' 
  AND token = 'F8GkIM9kfl/gO0t+tIbyeAPrwB2MBJwP3HO2aZvSyfo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}