SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'a51454f0efbd7591158840e7bc8e5a268a8aa965a38b47be1a1b4180782c70a7' 
  AND token = 'gLtqjxgl2iYAqRznd4rmJhW3Gwy4ciDDVVmUp2wYp9c=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00015

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}