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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'ff00c5cf37e09bc882f63f2f7bec3b0987408f32f234a741ce24674e64afa295' 
  AND token = 'sEG8BxBjcPYCE+a9RfmJFT9d1UDqSbxhfpLHOUAIh/M=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}