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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '549d7bb2cd07338e1648720817e4e5f9eefa272ee0da65de9f6b71c530f6f530' 
  AND token = 'EzbzNsZ9LX1ksEGu0//iTW/TKCi8eTBO0NvTKCzfuYg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}