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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'f11d00df5583865fc287384d9f000d37999f68efe1c2f3dc747bd44a12187201' 
  AND token = 'emeGTj3fF1a+af/Eerv2jr37nciPwVWblClJCG9In00=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00015

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}